2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Chloride Channel

Chloride Channel

Cl− Channels

Chloride Channel

Related Products

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Chloride channels belong to a superfamily of ion channels that permit passive passage of anions, mainly chloride, across cell membrane. Chloride channels perform important roles in the regulation of cellular excitability, in transepithelial transport, cell volume regulation, and acidification of intracellular organelles. Chloride channels represent a group of potential drug targets.

The chloride channel protein (ClC) family comprises both chloride (Cl-) channels and chloride/proton (Cl-/H+) antiporters. In prokaryotes and eukaryotes, these proteins mediate the movement of Cl- ions across the membrane. In eukaryotes, ClC proteins play a role in the stabilization of membrane potential, epithelial ion transport, hippocampal neuroprotection, cardiac pacemaker activity and vesicular acidification.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-145603S
    Vanzacaftor-d4
    Vanzacaftor-d4 (VX-121-d4) is the deuterium labeled Vanzacaftor (HY-145603). Vanzacaftor is an orally active noval corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves processing and trafficking of CFTR protein as well as increases chloride transport in triple combined with Tezacaftor (HY-15448) and Deutivacaftor. Vanzacaftor-Tezacaftor-Deutivacaftor is safe and well tolerated, improving lung function, respiratory symptoms, and CFTR function with cystic fibrosis, which is promising for research in the field of cystic fibrosis diseases.
    Vanzacaftor-d<sub>4</sub>
  • HY-B0679R
    Lubiprostone (Standard)
    		Activator
    Lubiprostone (Standard) is the analytical standard of Lubiprostone. This product is intended for research and analytical applications. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research.
    Lubiprostone (Standard)
  • HY-N2057R
    Steviol (Standard)
    		Inhibitor
    Steviol (Standard) is the analytical standard of Steviol (HY-N2057). This product is intended for research and analytical applications. Steviol is the main metabolite of steviol glycosides and an inhibitor of AQP2/CFTR. Steviol slows down the growth of renal cysts by inhibiting the activity of CFTR, reducing the expression of AQP2, and promoting the degradation of AQP2 and CFTR. Steviol can be used in the research of polycystic kidney disease.
    Steviol (Standard)
  • HY-118233
    Alilusem potassium
    		Inhibitor
    Alilusem potassium is a diuretic. In anesthetized dogs undergoing water diuresis, Alilusem potassium effectively decreased free water clearance and increased Na+ and Cl- levels in excreted urine. When combined with Furosemide (HY-B0135) or Hydrochlorothiazid, Alilusem potassium further inhibited free water clearance. Alilusem potassium inhibited the lumen-positive transepithelial voltage and lumen-to-cistern Cl- flux in isolated rabbit cortical thick ascending limbs of Henle.
    Alilusem potassium
  • HY-B0493S
    Niflumic Acid-d5
    		Inhibitor
    Niflumic Acid-d5 is the deuterium labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
    Niflumic Acid-d<sub>5</sub>
  • HY-B0680
    Lubiprostone (hemiketal)
    		Activator
    Lubiprostone (hemiketal) (RU-0211 (hemiketal)) is a selective chloride channel 2 (CLCN2) activator. Lubiprostone (hemiketal) is used to treat chronic idiopathic constipation and opioid-induced constipation by activating CLCN2 channels to increase chloride ion secretion in the intestine, thereby increasing intestinal fluid secretion and enhancing intestinal peristalsis. Lubiprostone (hemiketal) can be used in the study of chronic constipation and cancer.
    Lubiprostone (hemiketal)
  • HY-W011240R
    Hydroflumethiazide (Standard)
    Hydroflumethiazide (Standard) is the analytical standard of Hydroflumethiazide. This product is intended for research and analytical applications. Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas.
    Hydroflumethiazide (Standard)
  • HY-P10226
    PGD97
    		Inhibitor
    PGD97 is a selective cyclic peptide inhibitor against CAL/CFTR interactions, with a KD value of 6 nM towards the CAL PDZ domain for its desulfide cyclized form. PGD97 (desulfide cyclized form) has selectivity ≥ 130-fold compared to NHERF1/2 PDZ domains. PGD97 is capable of stabilizing F508del-CFTR at the cell membrane and improving CFTR function required for proper fluid homeostasis in tne lung. PGD97 can be used for the research of cystic fibrosis.
    PGD97
  • HY-A0234R
    Stepronin (Standard)
    		Inhibitor
    Stepronin (Standard) is the analytical standard of Stepronin. This product is intended for research and analytical applications. Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands.
    Stepronin (Standard)
  • HY-B0679S
    Lubiprostone-d7
    		Activator
    Lubiprostone-d7 (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research.
    Lubiprostone-d<sub>7</sub>
  • HY-108772
    Crofelemer
    		Modulator
    Crofelemer (Provir) is an orally active antidiarrheal agent. Crofelemer acts on the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC) , which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer can be used in the research of diarrheal diseases.
    Crofelemer
  • HY-101329R
    Anthracene-9-carboxylic acid (Standard)
    		Inhibitor
    Anthracene-9-carboxylic acid (Standard) is the analytical standard of Anthracene-9-carboxylic acid. This product is intended for research and analytical applications. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells.
    Anthracene-9-carboxylic acid (Standard)
  • HY-126038
    BTS 39542
    		Inhibitor
    BTS 39542 is an orally active inhibitor for Na+ K+ Cl cotransport system, that exhibits diuretic activity, and can be used in hypertension and edema research.
    BTS 39542
  • HY-101012R
    NPPB (Standard)
    		Inhibitor
    NPPB (Standard) is the analytical standard of NPPB. This product is intended for research and analytical applications. NPPB is a blocker of the outwardly rectifying chloride channel (ORCC).
    NPPB (Standard)
  • HY-174441
    Molluscicidal agent-2
    		Antagonist
    Molluscicidal agent-2 (Compound 16) is a molluscicide with an LC50 of 0.58 mg/mL against Monacha cartusiana snails. Molluscicidal agent-2 exerts its effect through a dual mode of action: gastrointestinal toxicity and GABAA-GluCl channel antagonism. Molluscicidal agent-2 can be used in research on agricultural pest control.
    Molluscicidal agent-2
  • HY-B0908R
    Meticrane (Standard)
    		Inhibitor
    Meticrane (Standard) is the analytical standard of Meticrane. This product is intended for research and analytical applications. Meticrane is a diuretic. Meticrane inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. Meticrane is used to treat essential hypertension.
    Meticrane (Standard)
Cat. No. Product Name / Synonyms Application Reactivity